Scalloped hemline. Shell: 86% polyester, 14% spandex; Inner Shorts: 89% polyester, 11% spandex. Machine wash, tumble dry. The right attitude is not “you should get to bed at a reasonable time,” since I often get bursts of productivity between 11pm and 4am. What is a “regular user” though? Someone with ADHD taking adderall in the morning to boost the “executive function” of his brain during the day? (as someone with ADHD, adderall sedates my hyperactive brain as opposed to its intended effect, look up the stimulant paradox for more on this) Someone who takes adderall the night before a big test to pull an all nighter of productive studying? I personally never heard of anyone (without ADHD) who regularly takes amphetamines to boost waking hour productivity. Modafinil has related but different effects, regular modafinil users take it to offset the reduced mental performance brought about by sleep deprivation.

In each of these mouse models there is innate enhancement of airway hyper responsiveness (AHR), as well as ozone or ovalbumin induced airway inflammation (or sensitisation) and responsiveness that is greater than that observed in lean wild type controls, suggesting that increased BMI in humans may predispose to AHR, a cardinal feature of asthma.23 26 However, although increased AHR is observed in obese mice, lung inflammation may not be the mechanism by which this occurs. A recent report by Johnston et al23 paradoxically showed fewer inflammatory cells (eg, eosinophils and lymphocytes) in the bronchoalveolar lavage fluid following ovalbumin sensitisation in obese compared with lean mice. Ozone exposure, on the other hand, consistently increased lung inflammation more in the obese mice than in the lean animals.24 Additionally, adipokines appear to play a prominent role in modulating the risk of asthma in animal models.

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