Background. Interleukin 1 (IL 1) and tumor necrosis factor (TNF) are potent induces of prostaglandin (PG) synthesis and injection of PGE, IL 1, or TNF decreases food intake in healthy animals, whereas the anorexigenic effects of injected IL 1 and TNF are blocked by inhibitors of PG synthesis. It has been hypothesized that host secretion of IL 1 and TNF contribute to tumor induced anorexia.
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